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Afbeelding kan het volgende bevatten: de tekst 'Qiao full citation Abstract OBJECTIVE: To investigate the cardiac fibrosis model of ibuprofen type diabetes. by ibuprofen weeks. was injecting streptozotocin into the rats. pioglitazone by gavage for and components the renin-angiotensin system, transforming β1 and the mammalian target (mTOR) were evaluated by histopathological, immunohistochemical, Western blot analysis or Obvious cardiac fibrosis was detected diabetic group alleviated buprofen treatment. enzyme (ACE), receptor (AT1- Ang(1-7) R) levels receptor (Ang) higher, Angll ACE2 group. diabetic ameliorated by and changes and hearts the diabetic attenuated by ibuprofen treatment. significant difference between the ibuprofen and the pioglitazone groups. CONCLUSION: Ibuprofen could ameliorate'

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